The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) plays a major role in treatment resistance, from the development of vaccines to therapeutic drugs. In addressing the crux of the issue, various attempts to estimate the mutation rate of HIV-1 resulted in a large range of 10−5–10−3 errors/bp/cycle due to the use of different types of investigation methods.
ReadThe therapeutic potential of immunoglobulin M (IgM) is of considerable interest in immunotherapy due to its complement-activating and cell-agglutinating abilities. Pertuzumab and Trastuzumab are monoclonal antibodies used to treat human epidermal growth factor receptor 2 (HER2)-positive breast cancer but exhibit significantly different binding affinities as IgM when compared to its IgG isotype.
ReadBeing often irregular in shape, accurate measurements of wounds are often challenging. Tracing or length measurement by the longest dimension are often inaccurate and time-consuming to carry out. Yet, proper wound area monitoring is essential for wound care. Instead of multiple clinical visits, which also increase the burden on health care systems and the associated expenses, patients can take the responsibility for their own wound progress.
ReadThe intriguing relationship between microbiota and human psyche showed gut microbiota to be associated with well-being. To determine if the microbiota of other body parts would be similarly associated, we analyzed the perceived stress, well-being, and happiness scale measures of 106 healthy individuals and their aerotolerant microbiota load in their otorhino canals.
ReadArea measurements have a wide range of uses from the monitoring of skin features in healthcare, celestial bodies in astronomy, to determining furniture sizes in everyday indoor uses. Current measurement methods utilize some form of measuring tool and unless performed by skilled and trained professionals, human errors leading to inaccurate measurements can often arise.
ReadWith the latest technologies enabling smartphones to work like mini computers, there are now numerous opportunities to use smartphones for the development of mobile apps. Given the multiple Operating Systems (OS) available, there is a significant demand for apps for the various platforms.
ReadThe reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the sum of its parts. With experimental, technological and computational advances, we can now do more than view parts in isolation, thus wepropose that an increasing holistic view (where a protein is investigated as much as a whole as possible) is now timely.
ReadThe average scientific publication is not the most palatable of reading materials, especially to those not in the relevant disciplines. Yet, conveying scientific concepts easily is precisely what scientific publications are meant to do. Imagine what the use of video pictures/paintings as depicted in the Harry Potter movie series can do to make things easier!
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